- A Case of Intracranial Hypotension and Unilateral Positional Hearing Impairment with MRI Findings
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Jae-Wook Jung, Ki-Moon Jang, Hyung-Woo Lee, Min-Kyung Chu
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Published online December 31, 2018
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- 자발두개내저압과 경부인성두통에 의해 연속적으로 발생한 기립두통 1례
- 심도의 편두통관련 장애와 관계된 인자
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Hye-Lim Kim, Mi-Sun Oh, Kyung-Ho Yu, Hyeo-Il Ma, Joo-Yong Kim, Byung-Chul Lee, Min-Kyung Chu
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Korean J Headache. 2011;12(1):49-56. Published online June 30, 2011
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- Background
Migraine is a heterogeneous condition that results in a spectrum of disability among individuals. Under- standing factors associated with severe disability of migraine is an important step towards optimizing interventions. Objective: To describe factors associated with severe migraine-related disability. Methods: We assessed factors of severe disability in univariate and multivariate analyses. Multivariate analyses were adjusted for demographic factors, clinical features, headache severity and frequency. Results: One hundred and ninety migraine patients were enrolled in this study. In the unadjusted univariate analyses, severe pain was associated with severe disability compared to mild pain. Aggravation by routing physical activity, pho- tophobia, visual aura and eyeball pain were associated with severe disability of migraine. Taking less than 4 headache days per month as the reference, ≥15 headache days per month was associated with severe disability. In the adjusted multivariate analyses, aggravation by routine physical activity, visual aura and ≥15 headache days per month were associated with severe migraine-related disability. Conclusions: These results demonstrated that a significant proportion of migraine sufferers had severe disability and there are specific factors associated with severe disability.
- 편두통 예방치료
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Jae-Myun Chung, Min-Kyung Chu
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Korean J Headache. 2009;10(1):19-34. Published online June 30, 2009
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- Migraine is a chronic recurrent headache disorder that is common in general population. Its burden of socioeconomical aspect as well as personal psychologic aspect makes migraine as one of the most disabling disorders. In addition to acute treatment of migraine, preventive treatment is required in those with frequent or disabling attacks of migraine to minimize the disability, to prevent medication overuse, and to improve the quality of life. In this review, we discuss the principles of migraine prevention, and clinical applications of medications for this purpose which include beta blockers, calcium channel blockers, antidepressants and anticonvulsants as well as newly emerging drugs such as angiotensin-converting enzyme inhibitor, angiotensin-receptor blocker, coenzyme Q10, riboflavin and magnesium. Nonpharmacologic management for migraine prevention is an another important treatment strategy. Considering underdiagnosis and undertreatment of migraine, the knowledge about applying appropriate preventive management is essential for any physician irrespective of specialty.
- 한국인 두통 환자에서 두통 발작 시 냄새공포증과 무전조편두통 대체 진단기준의 타당도 평가
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Ji-Young Kim, Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yun Joong Kim, Joo-Yong Kim, Byung-Chul Lee
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Korean J Headache. 2007;8(2):92-96. Published online December 31, 2007
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Sensory system may be activated during migraine attacks. Visual and auditory system activation have been addressed and implicated as an item of ICHD-II migraine diagnostic criteria. Recently the activation of olfactory systems during migraine attack has been occasionally commented. The object of this study is to assess osmophobia and validation of alternative diagnostic criteria of migraine without aura in Korean headache patients Methods: One hundred eighteen headache patients who visited outpatient clinic from August 2007 to October 2007, were evaluated for characteristics and associated features of headache such as frequency, duration, location, quality of pain, nausea, vomiting, photophobia, phonophobia and osmophobia. Osmophobia was classified as hyperosmia, hyposmia and dysosmia. Results: Eighty patients(67.8%) were diagnosed as having migraine and twenty four patients(20.3%) were diagnosed as having tension-type headache according to ICHD-II. Six patients were diagnosed as having probable migraine, two patients were diagnosed as having probable tension-type headache, two patients were diagnosed as having cluster headache and four patients were diagnosed as other primary headache. Thirty one patients complained of osmophobia during headache(90.3% very frequently and 9.7% frequently). Thirteen of them reported hypersomia (41.9%), seventeen reported dysosmia(54.8%) and one reported hyposmia(3.3%). All patients who complained of osmophobia during headache attacks were migraneurs. According to alternative diagnostic criteria of migraine without aura, 61 patients were diagnosed as having migraine without aura. Sensitivity of alternative diagnostic criteria was 0.85(95% CI, 0.74- 0.91) and specificity was 1.00(95% CI, 0.93-1.00). Conclusions: Osmophobia was observed in around 40% of migraineurs and was specific to migraine. Alternative dia- gnostic criteria of migraine without aura may be a valid method of classification.
- 자가편두통 선별 도구의 개발 및 타당도 평가 -한국 편두통 선별 설문-
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Min-Kyung Chu, Byung Kun Kim, Sung Taek Kim, Jae-Moon Kim, Heui-Soo Moon, Jeong Wook Park, Kwang-Soo Lee, Kyung-Mi Oh, Jae-Myun Chung, Chin-Sang Chunge
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Korean J Headache. 2007;8(2):84-91. Published online December 31, 2007
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- Background
Migraine is a common and disabling illness. But substantial migraine sufferers were underdiagnosed or undiagnosed. To improve migraine diagnosis, Korean Migraine Screening Questionnaire(KMSQ) was developed and validated in outpatient setting. Methods: A total of 507 patients who visited out patient clinic for headache were recruited in 10 hospitals in Korea and asked 10-item questionnaire concerning headache. 487 completed and returned the questionnaire. All patients were evaluated for headache and diagnosed by headache experts. Migraine diagnosis was assigned on International Head- ache Society(IHS) criteria after completing semi-structured diagnostic interview. Results: Of ten diagnostic questions derived from IHS criteria and headache expert experience, three-item subsets were deduced. Combination of questions regarding nausea, pulsating quality and photophobia showed optimum perfor- mances. Any two from the three items showed a sensitivity of 0.74, a specificity of 0.80, a positive predictive value of 80.8 and a negative predictive value of 73.5. Conclusion: The three-item Korean Migraine Screening Questionnaire was a valid and reliable migraine screening instru- ment in outpatient setting. It could help in improvement of migraine diagnosis and enhance migraine management.
- 만성매일두통의 정의와 분류
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Min-Kyung Chu, Ph.D.
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Korean J Headache. 2007;8(1):1-5. Published online June 30, 2007
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- Chronic daily headache(CDH) refers to a category of headache disorders that are characterized by headaches occurring on more than 15 days per months. This category subdivided into primary and secondary CDH disorders. Common primary CDH disorders included transformed migraine, chronic migraine, new daily persistent headache, medication overuse headache and hemicrania continua. According to ICHD-II criteria, most CDH has more than one diagnosis. Chronic migraine in ICHD-II is restrictive and only small portion of CDH patients were diagnosed as chronic migraine. Silberstein and Lipton proposed transformed migraine for frequent association of migraine and migrainous features in CDH. In 2005, revised diagnostic criteria for broader concept of chronic migraine was ented in appendix of ICHD-II. According to new criteria, more than 80% of CDH patients were classified as having chronic migraine.
- 종설 : 새로운 편두통 치료 약물
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Min-Kyung Chu
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Korean J Headache. 2006;7(2):71-78. Published online December 31, 2006
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- Migraine is a common, disabling headache disorder and imposes a significant burden personally and socially. Recent advances in migraine treatment including new drugs for acute and preventive treatment make it possible for more effective migraine management. Newly introduced acute treatment drugs are second generation triptans, calcitonin gene- related related peptide receptor antagonist, 5-HT1D receptor inhibitor, and adenosine A1 receptor agonist. Second genera- tion triptans are almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan and zolmitriptan. New triptans offer more oral efficacy, a better adverse-event profile, a more rapid onset of action and a better response consistency. Newly introduced drugs for migraine preventive treatment are topiramate, zonisamide, levetiracetam, venlafaxine, botulinum toxin, lisinopril, candesartan, riboflavin, coenzyme Q10, magnesium, feverfew and petasites. Newly introduced migraine treatment drugs would help for more successful management of migraine.
- 한국에서 편두통 예방 치료를 위한 평가 - 편두통에 의한 장애인식 캠페인 -
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Min-Kyung Chu, Sun Uck Kwon, Manho Kim, Byung-Kun Kim, Byung-Joo Kim, Yeong-In Kim, Yong-Jae Kim, Won-Joo Kim, Jae-Moon Kim, Hyun Sook Kim, Jin Kuk Do, Ki-Jong Park@
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Korean J Headache. 2005;6(2):121-128. Published online December 31, 2005
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- Background
Migraine is a common, disabling illness and imposes great burden on society. Migraine- related disability is often poorly communicated between patients and physicians. The prevalence, disability and medical service utilization behavior of migraine has not been evaluated sufficiently in Korea. The goal of this study is to determine the proportion of migraine among patients presented with headache in neurology clinic and to assess the level of headache related disability of patients.
Methods
This survey recruited patients who consulted to neurologists with a chief complaint of headache in 17 hospitals in Korea. Patients answered a self-administered questionnaire. The investigators independently responded another questionnaire about their patients' headache and assessed headache related disabilities after diagnostic interview. Patients suffering from headache ≥15 days per month were excluded.
Results
Among 570 patients (female 433 (76.0%), mean age 47.8±15.6) who responded adequately the questionnaire, 376 patients had migraine. Fifty-eight percent of the migraine patients were newly diagnosed as having migraine through this survey. However, 74.9% of migraineurs have taken pain-relieving drugs when headache developed; 12.3% of the migraineurs overused the medications. One hundred forty one (37.5%) migraineurs reported that they miss family, social and leisure activities because of headache. Thirty percents of migraineurs were on prophylactic medications and 14.4% of them have visited emergency room due to severe headache. The neurologists would recommend prophylactic medication in 64.3% of patients who were not on prophylaxis.
Conclusions
This study showed that migraine is the most common headache syndrome in the neu- rology clinics of Korea. Significant portion of the migraine patients have migraine-related disability. A majority of migraineurs exposed pain-relieving drugs without exact diagnosis and some of them overused them. Korean Journal of Headache 6(2):121-128, 2005
- 일반연제-Restless Leg Syndrome in Migraineurs- Hallym University Migraine in Nurses Study -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon Kim, Joo-Yong Kim, Su-Jin Cho, Cheol-Ho Kim, Hong-Ki Song , Byung-Chul Lee
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Korean J Headache. 2005;6(1):104-104. Published online June 30, 2005
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and Objectives: Restless leg syndrome(RLS) is a prevalent disease which is often mis- diagnosed or underdiagnosed. RLS and migraine share some clinical features such as depression, sleep disorders, hemodialysis and positive family history of the disease. We analyzed the data of Hallym uni- versity migraine in nurses study to identify the association of RLS and migraine. Method: All 1501 nurses working at Hallym Medical Center were asked 72-item questionnaire on migraine including general information, occupational environments and characteristics, characteristics of headache, triggering factors, management of headache and migraine related disabilities. The diagnosis of RLS was made according to 3-item question set which was incorporated in the above questionnaire. The completed questionnaires were analyzed for the association of RLS and migraine. Results: 1341(89.3%) participants completed the questionnaire. All were female with mean age of 27.5±5.7. Based on ICHD-II, 276(17.5%) had migraine. Among migraineurs, 57(20.6%) have aura. 23(1.7%) had RLS and 9(39.1%) of them had migraine. The prevalence of RLS was significantly higher among migraineurs(3.4%) than non-migraineurs(1.3%). Migraineurs with RLS had tendency to have more aura than migraineurs without RLS. There was no significant difference in attack frequency, headache severity and MIDAS scores between migraineurs with RLS and migraineurs without RLS. Conclusion: There was significantly higher prevalence of RLS among migraineurs. Migraine with RLS showed tendency to have more aura.
- 간호사들의 월경관련 편두통 - 한림대학교 간호사 편두통 연구 -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon Kim, Joo-Yong Kim, Su-Jin Cho, Cheol-Ho Kim, Byung-Chul Lee
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Korean J Headache. 2005;6(1):74-81. Published online June 30, 2005
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& Objectives: It is known that migraines in women are associated with menstruation. We analyzed the data of Hallym university migraine in nurses study to identify the prevalence and clinical features of menstruation related migraine in Korean nurses. Method: All 1501 nurses working at Hallym Medical Center were asked 72-item questionnaire on mig- raine including general information, occupational environments and characteristics, characteristics of headache, triggering factors, management of headache and migraine related disabilities. We categorized participants as having menstrually associated migrtaine(MAM) who answered that migraine attacks were associated to menstruation. Results: 89.2% of participants completed the questionnaire. All were female with mean age of 27.5±5.7, 276(17.5%) were classified as having migraine. 59(25.0%) of migraineurs had MAM. 36(61.0%) had migraine attacks in premenstrual period, 13(22.0%) in menstruation period, 1(1.7%) in postmenstrual period. 9(15.3%) of migraineurs reported varying relationship between migraine attacks and menstruation. Headache aggravation by routine physical activity was more common in MAM than non-MAM. There were no signi- ficant difference in attack frequency, headache severity and MIDAS scores between MAM and non-MAM. Conclusion: 25.0% of nurses with migraine had MAM. Migraine attacks occurring in premenstrual period was the most common form of MAM. MAM showed some different clinical features from those of non-MAM. Korean Journal of Headache 6(1):74-81, 2005
- 10대 편두통 환자에서 발생한 모자이크양상의 일과성 흑암시
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Min-Kyung Chu, Young-Hoon Yoon, Hee-Chan Choi, Kyung-Ho Yu, Woo-Kyung Kim, Hong-Ki Song, Byung-Chul Lee, Ju-Hun Lee
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Korean J Headache. 2004;5(2):148-152. Published online December 31, 2004
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- Transient monocular blindness(amaurosis fugax) is uncommon in young people and its mechanism is rarely demonstrated. We report a case of young patient with recurrent amaurosis fugax of mosaic pattern. A 18 year-old female migraineur experienced recurrent episodes of monocular blindness of her left eye, which clustered over 3 weeks. The episodes lasted for 3 to 10 minutes and were not associated with head- ache. She reported that visual loss began as several dark spots scattered on the visual field which enlar- ged slowly over one to three minutes and eventually coalesced, resulting complete blindness in affected eye. After a few minutes, the vision returned in a reverse pattern; patches of vision eventually enlarging to full field. Intracranial and extracranial cerebral arteries were normal on magnetic resonance angiography. After propranolol medication, the attack was no longer observed. Amaurosis fugax in young people have different patterns of visual loss from those in elderly. The mosaic pattern of transient monocular blind- ness in young people suggested a migraine variant with benign prognosis. Korean Journal of Headache 5(2):148-152, 2004
- Effects of Shift Working on Migraine - Hallym Medical Center Nurse Study -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon-Jung Kim, Joo-Yong Kim, Hong- Ki Song, Byung-Chul Lee
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Korean J Headache. 2004;5(1):107-107. Published online June 30, 2004
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It is well known that migraine is related to sleep. Shift working was also reported as a triggering factor of migraine. The impact of shift working on migraine prevalence, frequency, and migraine related quality of life were not studied yet. The purposes of our study is to elucidate the relationship between shift working with migraine prevalence, attack frequency and migraine related quality of life. Method: All 401 nurses working at Hallym University Sacred Heart hospital were asked a 72-item questionnaire concerning migraine prevalence, attack frequency, migraine disability assessment(MIDAS), and Epworth sleepiness scale(ESS). The returned questionnaire was analyzed on the basis of the existence of shift working(SW). Result: Three hundreds seventy two nurses completed and returned the questionnaire for a response rate of 93.0%. According to International Headache Society criteria, 18.8% of the responding nurses were classified as having migraine. 285 of them were SW nurses. 58 of the SW nurses have migraine. 65.6% of the SW nurses with migraine answered that migraine was related to SW and night working was the most common working time related to migraine. Migraine prevalence, attack frequency, and MIDAS scores were not significantly different between SW and non-shift working(NoSW) nurses. ESS score was significantly higher in SW nurses than NoSW nurses. In NoSW nurses, sleepiness was related to migraine prevalence. However, sleepiness was not related to migraine prevalence in SW nurses. Conclusion: Even though many nurses believed that SW was a triggering factor for migraine attack, there were no significant differences in migraine prevalence, attack frequency, and migraine related quality of life between SW and NoSW nurses. Sleepiness was related to migraine prevalence in NoSW nurses. Revealing the relationship between migraine and SW would help for both unveiling the nature of disease and the effective management of migraine. Korean Journal of Headache 5(1):107-107, 2004
- 주야 교대 근무가 편두통에 미치는 영향 - 한림대학교 의료원 간호사 연구 -
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Min-Kyung Chu, Kyung-Ho Yu, Hyeo-Il Ma, Yoon-Jung Kim, Joo-Yong Kim, Hong- Ki Song, Byung-Chul Lee
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Korean J Headache. 2004;5(1):83-89. Published online June 30, 2004
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It is well known that migraine is related to sleep. Shift working was also reported as a triggering factor of migraine. The impact of shift working on migraine prevalence, frequency, and migraine related quality of life were not studied yet. The purposes of our study is to elucidate the relationship between shift working with migraine prevalence, attack frequency and migraine related quality of life. Method: All 401 nurses working at Hallym University Sacred Heart hospital were asked a 72-item questionnaire concerning migraine prevalence, attack frequency, migraine disability assessment(MIDAS), and Epworth sleepiness scale(ESS). The returned questionnaire was analyzed on the basis of the existence of shift working(SW). Result: Three hundreds seventy two nurses completed and returned the questionnaire for a response rate of 93.0%. According to International Headache Society criteria, 18.8% of the responding nurses were classified as having migraine. 285 of them were SW nurses. 58 of the SW nurses have migraine. 65.6% of the SW nurses with migraine answered that migraine was related to SW and night working was the most common working time related to migraine. Migraine prevalence, attack frequency, and MIDAS scores were not significantly different between SW and non-shift working(NoSW) nurses. ESS score was significantly higher in SW nurses than NoSW nurses. In NoSW nurses, sleepiness was related to migraine prevalence. However, sleepiness was not related to migraine prevalence in SW nurses. Conclusion: Even though many nurses believed that SW was a triggering factor for migraine attack, there were no significant differences in migraine prevalence, attack frequency, and migraine related quality of life between SW and NoSW nurses. Sleepiness was related to migraine prevalence in NoSW nurses. Revealing the relationship between migraine and SW would help for both unveiling the nature of disease and the effective management of migraine. Korean Journal of Headache 5(1):83-89, 2004
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